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Page 1
p52 expression enhances lung cancer progression.
Saxon JA, Yu H, Polosukhin VV, Stathopoulos GT, Gleaves LA, McLoed AG, Massion PP, Yull FE, Zhao Z, Blackwell TS. Saxon JA, et al. Sci Rep. 2018 Apr 17;8(1):6078. doi: 10.1038/s41598-018-24488-8. Sci Rep. 2018. PMID: 29666445 Free PMC article.
While many studies have demonstrated that canonical NF-kappaB signaling is a central pathway in lung tumorigenesis, the role of non-canonical NF-kappaB signaling in lung cancer remains undefined. ...Using gene expression and patient information from The Ca …
While many studies have demonstrated that canonical NF-kappaB signaling is a central pathway in lung tumorigenesis, the role of non-c …
Critical and distinct roles of cell type-specific NF-kappaB2 in lung cancer.
Sun F, Xiao Y, Shapiro SD, Qu Z, Xiao G. Sun F, et al. JCI Insight. 2024 Feb 22;9(4):e164188. doi: 10.1172/jci.insight.164188. JCI Insight. 2024. PMID: 38385745 Free PMC article.
On the other hand, NF-kappaB2 limited dendritic cell number and activation in the lung but protected lung macrophages and drove them to promote lung cancer through controlling activation of noncanonical and canonical NF-kappaB, respectively. ...These s …
On the other hand, NF-kappaB2 limited dendritic cell number and activation in the lung but protected lung macrophages and drov …
LncRNA AL139294.1 can be transported by extracellular vesicles to promote the oncogenic behaviour of recipient cells through activation of the Wnt and NF-kappaB2 pathways in non-small-cell lung cancer.
Ma X, Chen Z, Chen W, Chen Z, Shang Y, Zhao Y, Li L, Zhou C, He J, Meng X. Ma X, et al. J Exp Clin Cancer Res. 2024 Jan 16;43(1):20. doi: 10.1186/s13046-023-02939-z. J Exp Clin Cancer Res. 2024. PMID: 38229152 Free PMC article.
BACKGROUND: Extracellular vesicles (EVs) participate in cancer development via cell-to-cell communication. Long non-coding RNAs (lncRNAs), one component of EVs, can play an essential role in non-small-cell lung cancer (NSCLC) through EV-mediated delivery. ...
BACKGROUND: Extracellular vesicles (EVs) participate in cancer development via cell-to-cell communication. Long non-coding RNAs (lncR …
The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100.
Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z. Zhang Z, et al. J Biol Chem. 2015 Aug 7;290(32):19558-68. doi: 10.1074/jbc.M114.630061. Epub 2015 Jun 25. J Biol Chem. 2015. PMID: 26112410 Free PMC article.
Partial degradation of the p100 subunit to generate p52 subunit is a hallmark of the alternative NF-kappaB pathway, which has been implicated in cancer. Here, we uncovered a role of the p97-Npl4-Ufd1 complex in mediating p100-to-p52 processing and therefore positively regu …
Partial degradation of the p100 subunit to generate p52 subunit is a hallmark of the alternative NF-kappaB pathway, which has been implicate …
p52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment.
Saxon JA, Cheng DS, Han W, Polosukhin VV, McLoed AG, Richmond BW, Gleaves LA, Tanjore H, Sherrill TP, Barham W, Yull FE, Blackwell TS. Saxon JA, et al. J Immunol. 2016 Feb 15;196(4):1891-9. doi: 10.4049/jimmunol.1501555. Epub 2016 Jan 15. J Immunol. 2016. PMID: 26773153 Free PMC article.
Although numerous studies have demonstrated a critical role for canonical NF-kappaB signaling in inflammation and disease, the function of the noncanonical NF-kappaB pathway remains ill-defined. In lung tissue from patients with acute respiratory distress syndrome, we iden …
Although numerous studies have demonstrated a critical role for canonical NF-kappaB signaling in inflammation and disease, the function of t …
Comprehensive Evaluation of Nuclear Factor-kappabeta Expression Patterns in Non-Small Cell Lung Cancer.
Giopanou I, Lilis I, Papaleonidopoulos V, Marazioti A, Spella M, Vreka M, Papadaki H, Stathopoulos GT. Giopanou I, et al. PLoS One. 2015 Jul 6;10(7):e0132527. doi: 10.1371/journal.pone.0132527. eCollection 2015. PLoS One. 2015. PMID: 26147201 Free PMC article.
Nuclear factor (NF)-kappaB signalling is required for lung adenocarcinoma development in mice, and both of its subunits RelA and RelB were independently reported to be highly expressed in human non-small cell lung cancer (NSCLC). ...We conclude that pathologi …
Nuclear factor (NF)-kappaB signalling is required for lung adenocarcinoma development in mice, and both of its subunits RelA and RelB …
Functional polymorphisms in NFkappaB1/IkappaBalpha predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.
Huang D, Yang L, Liu Y, Zhou Y, Guo Y, Pan M, Wang Y, Tan Y, Zhong H, Hu M, Lu W, Ji W, Wang J, Ran P, Zhong N, Zhou Y, Lu J. Huang D, et al. Hum Genet. 2013 Apr;132(4):451-60. doi: 10.1007/s00439-013-1264-9. Epub 2013 Jan 16. Hum Genet. 2013. PMID: 23322360 Clinical Trial.
Lung inflammation is the major pathogenetic feature for both chronic obstructive pulmonary disease (COPD) and lung cancer. ...Here, we tested the hypothesis that single nucleotide polymorphisms (SNPs) in NFkappaB/IkappaB confer consistent risks for COPD and …
Lung inflammation is the major pathogenetic feature for both chronic obstructive pulmonary disease (COPD) and lung cancer …
ECCR1 and NFKB2 Polymorphisms as Potential Biomarkers of Non-small Cell Lung Cancer in a Polish Population.
Chaszczewska-Markowska M, Kosacka M, Chryplewicz A, Dyła T, Brzecka A, Bogunia-Kubik K. Chaszczewska-Markowska M, et al. Anticancer Res. 2019 Jun;39(6):3269-3272. doi: 10.21873/anticanres.13469. Anticancer Res. 2019. PMID: 31177178
BACKGROUND/AIM: Although genetic factors are presumed to account only for a part of the inter-individual variation in lung cancer susceptibility, the results are conflicting and there are no data available regarding the Polish population. We, therefore, performed a …
BACKGROUND/AIM: Although genetic factors are presumed to account only for a part of the inter-individual variation in lung cancer …
p52-Independent nuclear translocation of RelB promotes LPS-induced attachment.
Saito T, Sasaki CY, Rezanka LJ, Ghosh P, Longo DL. Saito T, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):235-41. doi: 10.1016/j.bbrc.2009.11.039. Epub 2009 Nov 10. Biochem Biophys Res Commun. 2010. PMID: 19903458 Free PMC article.
The NF-kappaB signaling pathways have a critical role in the development and progression of various cancers. In this study, we demonstrated that the small cell lung cancer cell line (SCLC) H69 expressed a unique NF-kappaB profile as compared to other cancer c …
The NF-kappaB signaling pathways have a critical role in the development and progression of various cancers. In this study, we demonstrated …
19 results